Knightwood Male Enhancement approaches discussed above will meet the needs of many tissue types fabrication of large tissues and whole organs Dino Moore remains a major challenge so this was around 2000 or so where people are seriously thinking about integrating how do we go about integrating vascular networks into these kinds of 3-dimensional constructs of extracellular matrices that we are trying to trying to build right so the clinicians came up with a with a it's a solution for this is and and the idea is that well if it is difficult to make vascular networks and structures why not start with something that already have it right so decellularized organs are a fantastic way to go about doing this so you can take a pig's organ and then completely desolate by washing with detergents and other things and over time you can remove it and all you have is the network with ECM and then you can reseed it with itself so Antonia Teller Baddeley and Archie Oni where some of the pioneers who started this this work and and it's it's a fantastic idea so you already have a three-dimensional network in there and you can seed cells with it and in some cases such as in vivo bio reactors for example this is a very feasible feasible approach the only issue with it is that if you want to move